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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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Cranial Ewing's sarcoma in children.

Maria Moschovi1, George A Alexiou, Natalia Tourkantoni

  • 1First Department of Pediatrics, University of Athens, Athens, Greece.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|March 3, 2011
PubMed
Summary
This summary is machine-generated.

We report rare cases of primary and radiation-induced skull Ewing sarcoma, a bone cancer. Both pediatric patients underwent successful surgery, showing a favorable outcome for this aggressive neoplasm.

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Area of Science:

  • Oncology
  • Pediatric Oncology
  • Skeletal Neoplasms

Background:

  • Ewing sarcoma is a rare, highly malignant bone cancer, representing 10% of primary bone malignancies.
  • Primary Ewing sarcoma of the skull vault is exceptionally rare, accounting for only 1-6% of all Ewing sarcoma cases.
  • Radiation-induced sarcomas are a known complication of cancer therapy.

Observation:

  • This report details two pediatric cases of skull Ewing sarcoma: one primary and one secondary to radiation therapy.
  • Clinical presentation, neuroimaging characteristics, and management strategies for these rare skull tumors were reviewed.
  • Both children presented with distinct symptoms and imaging findings necessitating tailored diagnostic and therapeutic approaches.

Findings:

  • Surgical intervention was performed for both primary and radiation-induced skull Ewing sarcoma.
  • Both pediatric patients achieved a favorable outcome following surgical management.
  • The review highlights the importance of considering radiation-induced sarcomas in the differential diagnosis of skull lesions.

Implications:

  • This case series contributes to understanding the rare occurrence and management of skull Ewing sarcoma.
  • Early diagnosis and prompt surgical treatment are crucial for favorable outcomes in pediatric skull Ewing sarcoma.
  • Further research into the specific risk factors and optimal treatment protocols for radiation-induced skull sarcomas is warranted.