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Updated: Jun 4, 2026

Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
Published on: November 12, 2015
An adenovirus traffic update: from receptor engagement to the nuclear pore
Daniel Henaff1, Sara Salinas, Eric J Kremer
1Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 34293 Montpellier, France.
Abstract:
Adenoviruses have a bipolar nature: they are ubiquitous pathogens that occasionally cause life-threatening diseases or they can be engineered into powerful gene transfer vectors. The goal of this article is to summarize the most recent advances in adenovirus receptor engagement, internalization, endosomal maturation, endosomal escape and trafficking to the nuclear pore. A better understanding of this initial part of the adenovirus lifecycle may identify new mechanistic-based treatments for adenovirus-induced diseases and help in the engineering of more efficient vectors.
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