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Updated: Jun 4, 2026
05:07
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Risk factors for intestinal ischaemia among patients registered in a UK primary care database: a nested case-control
C Huerta1, E Rivero, M A Montoro
1Centro Español de Investigación Farmacoepidemiológica, Almirante 28, Madrid, Spain.
Alimentary Pharmacology & Therapeutics
|March 4, 2011
Summary
Patients with irritable bowel syndrome and/or chronic constipation (IBS/CC) have a higher incidence of intestinal ischaemia compared to the general population. Different risk factors are associated with acute mesenteric ischaemia and ischaemic colitis.
Area of Science:
- Gastroenterology
- Vascular Surgery
- Epidemiology
Background:
- Intestinal ischaemia, encompassing ischaemic colitis and acute mesenteric ischaemia, is a significant cause of illness and death.
- Population-based data on the incidence and risk factors for intestinal ischaemia are limited.
Purpose of the Study:
- To determine the incidence of intestinal ischaemia.
- To identify risk factors for intestinal ischaemia in patients with irritable bowel syndrome and/or chronic constipation (IBS/CC) and in the general population.
Main Methods:
- A population-based case-control study was conducted within cohorts from the General Practice Research Database.
- The study included patients with IBS/CC/both and a control group from the general population.
Main Results:
- The incidence of intestinal ischaemia was higher in patients with IBS/CC/both (4.49 per 100,000 person-years) compared to the general population (1.09 per 100,000 person-years), with an adjusted incidence rate ratio of 2.7.
- Inflammatory bowel disease and heart failure were associated with ischaemic colitis.
- Diabetes and prior cardiovascular surgery were linked to acute mesenteric ischaemia.
Conclusions:
- Distinct risk factors are associated with acute mesenteric ischaemia and ischaemic colitis.
- The small patient numbers necessitate cautious interpretation of the identified associations.
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