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Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9
Rinku Dutta1, Michael D Scott, Manas K Haldar
1Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58102, USA.
Bioorganic & Medicinal Chemistry Letters
|March 4, 2011
Abstract
None:
Matrix metalloproteinases (MMPs) are overexpressed in various pathological conditions, including cancers. Although these isozymes have similar active sites, the patterns of exposed amino acids on their surfaces are different. Herein, we report the synthesis and molecular interactions of two water soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10.
