Related Experiment Video
Updated: Jun 4, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Intracoronary thrombin injection using a microcatheter to treat guidewire-induced coronary artery perforation
Tim A Fischell1, Soundos K Moualla, Santhosh R Mannem
1Borgess Heart Institute, Michigan State University, Kalamazoo, MI 49048, USA. tafisc@gmail.com
Abstract:
Coronary artery perforation (CAP) is an infrequent yet a very dangerous complication of percutaneous coronary intervention. We describe the successful treatment of a guidewire-induced distal coronary branch vessel perforation using localized distal injection of intracoronary thrombin with a microcatheter. This technique appears to be safe and effective for the treatment of life-threatening distal guidewire perforations, even in the smallest tertiary coronary branches.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Acute Coronary Syndrome I: Introduction

