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Updated: Jun 4, 2026

Adeno-Associated Virus-Mediated Delivery of CRISPR for Cardiac Gene Editing in Mice
Published on: August 2, 2018
Recombinant-adeno-associated viral vector-mediated gene therapy for cardiovascular diseases
Meizhen Zhang1, Hong Yuan, Zhijun Huang
1Center of Clinical Pharmacology, Third Xiangya Hospital, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Abstract:
Adeno-associated virus is a kind of DNA defective parvovirus which is non-pathogenic. Recombinant-adeno-associated virus vector comes from wild-type non-pathogenic adeno-associated virus and is highly secure, and it also has the advantages of broad host range. Recombinant-adeno-associated virus vector has become a hot spot for gene therapy and is widely used in gene therapy for cardiovascular diseases, especially for hypertension, heart failure, arteriosclerosis, and myocardial infarction.
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