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Related Experiment Videos

Mammographic changes associated with postmenopausal hormone replacement therapy: a longitudinal study.

P C Stomper1, B J Van Voorhis, V A Ravnikar

  • 1Department of Radiology, Roswell Park Memorial Institute, School of Medicine and Biomedical Science, SUNY, Buffalo 14263.

Radiology
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

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Postmenopausal hormone replacement therapy can cause benign increases in mammographic density. These changes may reduce mammography

Area of Science:

  • Radiology
  • Oncology
  • Endocrinology

Background:

  • Hormone replacement therapy (HRT) is commonly used by postmenopausal women.
  • Mammography is a crucial screening tool for breast cancer detection.
  • Changes in breast tissue density can affect mammographic interpretation.

Purpose of the Study:

  • To evaluate the frequency and types of mammographic changes in postmenopausal women undergoing HRT.
  • To assess the impact of HRT on breast tissue density and appearance on mammograms.

Main Methods:

  • Retrospective analysis of screen-film mammograms from 50 postmenopausal women.
  • Comparison of pre-treatment and post-treatment mammographic findings.
  • Assessment of mammographic changes including parenchymal density, asymmetry, and cyst formation.

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Main Results:

  • 24% of women showed increased parenchymal density after a median of 18 months of HRT.
  • Specific changes included diffuse density increase (14%), multifocal asymmetric densities (4%), and cyst formation (6%).
  • Estrogen-progesterone therapy showed a trend towards more changes than estrogen-alone therapy, but not statistically significant.

Conclusions:

  • Benign increases in mammographic density are a common finding in postmenopausal women using HRT.
  • Serial mammographic changes associated with HRT may potentially decrease the sensitivity of mammography for early breast cancer detection.