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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Related Experiment Videos

Data and knowledge management in cross-Omics research projects.

Martin Wiesinger1, Martin Haiduk, Marco Behr

  • 1Emergentec Biodevelopment GmbH, Vienna, Austria.

Methods in Molecular Biology (Clifton, N.J.)
|March 4, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a software concept for cross-omics data sharing and integration. It facilitates hypothesis generation and knowledge discovery from multi-level omics profiles in collaborative research settings.

Related Experiment Videos

Area of Science:

  • Multi-omics research
  • Systems Biology
  • Bioinformatics

Background:

  • Cross-omics studies integrating multiple data types (e.g., transcriptomics, proteomics) are increasingly important for understanding phenotypes.
  • Specialization in omics techniques necessitates collaborative efforts and effective data sharing.

Purpose of the Study:

  • To present a software concept and methodology for fostering omics data sharing in distributed research teams.
  • To enhance cross-omics data analysis, interpretation, and hypothesis generation.

Main Methods:

  • Development of a software concept focused on data management for omics data.
  • Implementation of features for hypothesis generation through inference and semantic search.
  • Inclusion of community functions to support collaborative research.

Main Results:

  • A methodology is described that supports investigators in managing and interpreting complex omics data workflows.
  • The software concept facilitates the transition from heterogeneous omics profiles to an integrated body of knowledge.
  • The approach supports data sharing in distributed team settings.

Conclusions:

  • The proposed software concept and methodology address the need for effective data sharing and integration in cross-omics research.
  • This approach supports collaborative hypothesis generation and knowledge discovery from multi-level omics data.
  • It aids in managing complex data workflows and interpreting integrated omics profiles.