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Molecular detection of multiple endocrine neoplasia type 2
1Department of Laborabory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Methods in Molecular Medicine
|March 4, 2011
Abstract:
Multiple endocrine neoplasia type 2 (MEN2) comprises three autosomal dominant disorders: MEN2A, familial medullary thyroid carcinoma (FMTC), and MEN2B. Clinical features common to both MEN2A and MEN2B include C-cell hyperplasia, medullary thyroid cancer (MTC), and pheochromocytoma. Other features of MEN2B are ocular and mucosal neuromas, gastrointestinal ganglioneuromatosis, and skeletal abnormalities. FMTC is characterized by MTC in the absence of parathyroid or adrenal disease.
