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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells
11:41

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

Stem cells in veterinary medicine.

Lisa A Fortier1, Alexander J Travis

  • 1Department of Clinical Sciences, Cornell University, VMC C3-181, Ithaca, NY 14850, USA. laf4@cornell.edu

Stem Cell Research & Therapy
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

Stem cell therapies are advancing in veterinary medicine, primarily for musculoskeletal injuries in horses and dogs. Research also explores using stem cells for conservation and creating animal models for human disease, though clinical use in animals is still developing.

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Area of Science:

  • Veterinary Medicine
  • Regenerative Medicine
  • Animal Science

Background:

  • The field of stem cell research in veterinary medicine is rapidly advancing both experimentally and clinically.
  • Current clinical applications predominantly focus on treating musculoskeletal injuries in horses and dogs.
  • Emerging technologies in assisted reproduction utilize stem cells for species preservation and generating transgenic animals.

Purpose of the Study:

  • To review animal model research supporting current clinical applications of stem cells in veterinary medicine.
  • To highlight the evolving therapeutic and biotechnological uses of stem cells in animals.
  • To contextualize preclinical research within the scope of existing veterinary stem cell treatments.

Main Methods:

  • Review of recent literature on stem cell applications in veterinary medicine.
  • Focus on studies that support or inform current clinical practices.
  • Exclusion of general reviews on animal models for stem cell research unless directly relevant to clinical support.

Main Results:

  • Stem cells are widely used clinically for musculoskeletal conditions in horses and dogs.
  • Spermatogonial stem cells show promise in assisted reproduction for conservation and generating transgenic animals.
  • Animal models are crucial for preclinical evaluation of stem cell therapies for conditions like spinal cord injury and myocardial infarction, though not yet clinically implemented in veterinary patients.

Conclusions:

  • Stem cell applications in veterinary medicine are expanding, with established uses in musculoskeletal injuries and potential in reproduction and disease modeling.
  • While animal models are valuable for research, their direct clinical translation in veterinary medicine requires further development.
  • This review emphasizes the supportive role of animal model research in advancing current clinical stem cell applications for animals.