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Related Experiment Video

Updated: Jun 3, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Pattern electroretinogram in glaucoma suspects: new findings from a longitudinal study.

Sebastian F N Bode1, Thomas Jehle, Michael Bach

  • 1Sektion Funktionelle Sehforschung, University Eye Hospital Freiburg, Freiburg, Germany.

Investigative Ophthalmology & Visual Science
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

The pattern electroretinogram (PERG) can detect glaucoma up to 4 years before visual field changes. The PERG ratio demonstrated high sensitivity and specificity in predicting glaucoma conversion in ocular hypertension patients.

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Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Early detection of glaucoma is crucial for preventing vision loss.
  • Glaucoma diagnosis often relies on visual field testing, which may detect changes late.
  • The pattern electroretinogram (PERG) assesses retinal ganglion cell function, offering a potential early diagnostic marker.

Purpose of the Study:

  • To evaluate the pattern electroretinogram (PERG) for early glaucoma detection in patients with ocular hypertension.
  • To assess the predictive value of PERG amplitude, ratio, and peak time for glaucoma conversion over a long-term prospective study.

Main Methods:

  • A prospective study included 120 eyes of 64 patients with ocular hypertension and followed them for a mean of 10.3 years.
  • PERG measures (amplitude, ratio, peak time) and visual fields were analyzed per visit and for trends.
  • Conversion to glaucoma was defined by visual field changes.

Main Results:

  • 13 eyes converted to glaucoma during the study.
  • Converters showed significantly lower PERG amplitude and PERG ratio compared to non-converters.
  • PERG ratio predicted conversion with 75% sensitivity and 76% specificity, up to 4 years prior to visual field changes.

Conclusions:

  • The PERG, particularly the PERG ratio, is a valuable tool for predicting glaucoma development years before visual field deficits are apparent.
  • Single-visit PERG measures, especially the PERG ratio, are effective for early glaucoma detection.
  • Longitudinal trend analysis of PERG provided limited additional predictive value over single-visit measures.