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OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery

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Published on: May 9, 2021

Does the bromocriptine-rebound method improve embryo quality?

Naoko Moride¹, Akira Kuwahara, Mizuho Yamashita

¹Department of Obstetrics and Gynecology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.

The Journal of Medical Investigation : JMI

|March 5, 2011

Summary

The bromocriptine-rebound (BR) method may improve pregnancy outcomes for women with prior unsuccessful assisted reproductive technology (ART) attempts. This method resulted in better embryo quality and higher clinical pregnancy rates compared to the standard long protocol.

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Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Area of Science:

Reproductive Endocrinology
Infertility Research
Assisted Reproductive Technology

Background:

Assisted reproductive technology (ART) success rates can be limited in women with a history of failed attempts.
Optimizing ovarian stimulation protocols is crucial for improving ART outcomes.
The bromocriptine-rebound (BR) method is an alternative approach for ovarian stimulation.

Purpose of the Study:

To evaluate the efficacy of the bromocriptine-rebound (BR) method in improving pregnancy outcomes.
To compare the BR method with the traditional long protocol in women with previous unsuccessful ART attempts.
To assess hormonal data and pregnancy-related parameters between the two protocols.

Main Methods:

Retrospective analysis of 121 women with normal prolactin levels and recurrent unsuccessful ART.
Comparison of pregnancy outcomes and hormonal data between the BR method and the long protocol.
BR method involved daily bromocriptine administration from day 5 of the preceding cycle until 7 days before stimulation.

Main Results:

The BR method yielded significantly higher numbers of fertilized oocytes, cleaved embryos, and transferred embryos compared to the long protocol.
Higher ratios of good-quality embryos and improved clinical pregnancy rates were observed with the BR method.
Embryo scores were significantly higher in the BR method group.

Conclusions:

The bromocriptine-rebound (BR) method demonstrates potential for generating better quality embryos.
The BR method may enhance embryo transplantation rates in women experiencing recurrent ART failures.
This approach offers a promising alternative for improving success in challenging ART cases.