Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
Clamper Circuit01:14

Clamper Circuit

A clamper circuit, also known as a DC restorer, represents a specialized variant of the rectifier circuit, notable for its method of taking the output across the diode rather than the capacitor. This configuration lends to several distinctive applications, particularly in handling square wave inputs.
Within this circuit, the diode's orientation prompts the capacitor to charge up to the level of the most negative peak of the input signal. Upon reaching this state, the diode ceases to conduct,...
Clipper Circuit01:18

Clipper Circuit

A clipper circuit is a fundamental wave-shaping device that harnesses the unique properties of diodes to alter and control waveform characteristics. This technology is widely used in electronic devices, especially in television and radar communication systems, where it enhances waveform modulation in both transmitters and receivers.
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...
Machines: Problem Solving I01:22

Machines: Problem Solving I

A toggle clamp is a mechanical device commonly used for holding and clamping objects in various applications, such as woodworking, metalworking, and assembly operations. Consider a toggle clamp subjected to a force of 200 N at the handle. The vertical clamping force can be calculated, provided the dimensions of the toggle clamp are known.
The toggle clamp system is a machine structure consisting of movable, pin-connected multi-force members that form a stabilized system to transmit forces. The...
Voltage Doubler Circuit01:23

Voltage Doubler Circuit

A voltage doubler circuit integrates two main components: a clamping section and a rectifier section. The clamping section consists of a capacitor (C1) and a diode (D1), whereas the rectifier section is equipped with another diode (D2) and capacitor (C2). This circuit produces an output voltage with twice the amplitude of the sinusoidal input voltage.
Time-Domain Interpretation of PD Control01:07

Time-Domain Interpretation of PD Control

Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wavelet-based visual compass.

PloS one·2026
Same author

Introduction to the Proceedings of the CNS*2025 Meeting.

Journal of computational neuroscience·2026
Same author

Efficient event-based delay learning in spiking neural networks.

Nature communications·2025
Same author

Building on models-a perspective for computational neuroscience.

Cerebral cortex (New York, N.Y. : 1991)·2025
Same author

miRNA-1175 downregulates a long non-coding natural antisense RNA and promotes long term memory.

Scientific reports·2025
Same author

Understanding the mechanism of facilitation in hoverfly TSDNs.

PLoS computational biology·2025

Related Experiment Video

Updated: Jun 3, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Dynamic clamp with StdpC software.

Ildikó Kemenes1, Vincenzo Marra, Michael Crossley

  • 1School of Life Sciences, University of Sussex, Brighton, UK.

Nature Protocols
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

A new open-source software, StdpC (spike timing-dependent plasticity clamp), simplifies dynamic clamp experiments. This powerful tool allows researchers to simulate cellular electrical components without specialized hardware or programming knowledge.

More Related Videos

Implementing Dynamic Clamp with Synaptic and Artificial Conductances in Mouse Retinal Ganglion Cells
11:46

Implementing Dynamic Clamp with Synaptic and Artificial Conductances in Mouse Retinal Ganglion Cells

Published on: May 16, 2013

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
08:34

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

Published on: May 9, 2021

Related Experiment Videos

Last Updated: Jun 3, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Implementing Dynamic Clamp with Synaptic and Artificial Conductances in Mouse Retinal Ganglion Cells
11:46

Implementing Dynamic Clamp with Synaptic and Artificial Conductances in Mouse Retinal Ganglion Cells

Published on: May 16, 2013

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
08:34

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

Published on: May 9, 2021

Area of Science:

  • Neuroscience
  • Computational Biology
  • Electrophysiology

Background:

  • Dynamic clamp is a crucial technique for simulating cellular electrical properties like ionic conductances and synaptic inputs.
  • It involves a real-time cycle of membrane potential measurement, current calculation, and current injection.
  • Existing methods often require specialized hardware, commercial software, and significant technical expertise.

Purpose of the Study:

  • To introduce a novel, accessible dynamic clamp protocol using free, open-source software.
  • To enable complex and automated dynamic clamp experiments with a user-friendly interface.
  • To reduce the technical barriers for researchers utilizing dynamic clamp methodology.

Main Methods:

  • Development and implementation of StdpC (spike timing-dependent plasticity clamp) software.
  • Utilizing a standard computer setup without specialized hardware or real-time operating systems.
  • Configuring and operating dynamic clamp experiments through an intuitive graphical interface.

Main Results:

  • StdpC software provides a fully integrated, open-source solution for dynamic clamp.
  • The protocol eliminates the need for specialist hardware, costly software, or advanced programming skills.
  • Complex, automated dynamic clamp experiments can be set up within hours and yield results within minutes of cell recording.

Conclusions:

  • StdpC significantly democratizes the use of dynamic clamp in neuroscience research.
  • The software facilitates rapid and efficient simulation of cellular electrical behaviors.
  • This approach lowers the entry barrier for researchers, promoting wider adoption of dynamic clamp techniques.