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Related Experiment Video

Updated: Jun 3, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Fluid supplementation in hyperbilirubinemia.

Shiv Sajan Saini1, Praveen Kumar, Karthik Balasubramanium

  • 1Newborn Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Indian Journal of Pediatrics
|March 5, 2011
PubMed
Summary

Fluid supplementation is less effective for severe hyperbilirubinemia in neonates born via cesarean or instrumental delivery. These delivery methods are linked to treatment failure in term infants with high bilirubin levels.

Related Experiment Videos

Last Updated: Jun 3, 2026

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
09:09

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

Published on: November 3, 2023

Area of Science:

  • Neonatal Medicine
  • Pediatric Gastroenterology
  • Clinical Pediatrics

Background:

  • Severe hyperbilirubinemia is a common condition in term neonates.
  • Fluid supplementation is a common adjunct therapy to phototherapy for hyperbilirubinemia.
  • Factors influencing the success of fluid supplementation require further investigation.

Purpose of the Study:

  • To identify factors associated with the failure of intravenous fluid supplementation in term neonates with severe non-hemolytic hyperbilirubinemia.
  • To compare characteristics of neonates who responded to fluid supplementation versus those who required exchange transfusion.

Main Methods:

  • Analysis of data from two prior randomized controlled trials involving term neonates (≥37 weeks) with severe hyperbilirubinemia (total bilirubin 18-25 mg/dL).
  • Neonates received intravenous fluid supplementation for 8 hours alongside phototherapy.
  • Comparison of baseline and changing serum bilirubin, sodium, and osmolality between responders and non-responders (those requiring exchange transfusion).

Main Results:

  • Of 121 neonates analyzed, 17 were non-responders and 104 were responders.
  • Non-responders had significantly higher mean baseline serum bilirubin and a higher incidence of cesarean/instrumental delivery.
  • Cesarean/instrumental delivery was identified as an independent predictor of treatment failure (OR 3.9).

Conclusions:

  • Intravenous fluid supplementation is less likely to be successful in treating severe non-hemolytic hyperbilirubinemia in neonates delivered via cesarean or instrumental delivery compared to normal vaginal delivery.
  • Mode of delivery is a significant factor to consider when assessing treatment response to fluid supplementation in neonatal hyperbilirubinemia.