Sex differences and hormonal influences in human sensorimotor gating: implications for schizophrenia

Prepulse inhibition (PPI) of the startle response serves to prevent the interruption of ongoing perceptual and early sensory analysis and provides a simple operational measure of sensorimotor gating. In line with postulated deficits in early stages of information processing, PPI is disrupted in schizophrenia. PPI is considered a valid candidate for an endophenotypic marker in genetic studies of schizophrenia and has also been extensively used in translational research. Importantly, there are well-replicated sex differences and menstrual phase effects in prepulse-elicited startle modulation of nonclinical young populations. Lack of knowledge about the precise roles of sex differences and hormonal effects in prepulse-elicited startle modulation and in the schizophrenia disease process presents a stumbling block to continuous progress in this field. This chapter reviews a wealth of data demonstrating sex and hormonal influences in prepulse-elicited startle modulation and considers their implications for our understanding of the pathophysiology, genetics, and potential treatments of schizophrenia.