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The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Aging of cultured human skin fibroblasts
1McMaster University, Hamilton, Ontario, Canada.
Methods in Molecular Biology (Clifton, N.J.)
|March 5, 2011
Abstract:
There is substantial evidence that aging is related to the finite ability of somatic cells to divide and repair damaged tissue. Since the seminal observation of Hayflick and Moor head (1) that cultured human fibroblasts have a finite replicative lifespan, a great deal of basic biological research on aging has been based on the model of cellular senescence in vitro (2).
