Related Experiment Video
Updated: Jun 3, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Acetonitrile stacking : serum phenobarbital as an example
1Department of Pathology, The Bowman Gray Medical School, Wake Forest University, Winston-Salem, NC.
Abstract:
Capillary electrophoresis (CE) has several advantages, such as high resolution, speed, and low cost of operation. However, it suffers from two major drawbacks: poor detection limits and matrix effects. Several approaches have been used to overcome these two problems. Here, acetonitrile stacking (AS) is presented as a simple, easy, and practical approach that can solve these two problems for many analytes, with minimum sample preparation. This laboratory successfully used AS for the analysis of several compounds by CE (1).
Related Concept Videos
Sedatives and Hypnotics Drugs: Barbiturates
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Depolarizing Blockers: Pharmocokinetics
Physical Properties of Amines

