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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Characterization of HCV-Specific Cytotoxic T-Lymphocytes from Liver Tissue
1Infectious Disease Division, Beth Israel-Deaconess Medical Center, Boston, MA.
Abstract:
Cellular immune responses, especially those mediated by cytotoxic T-lymphocytes (CTLs), are an important component of the host immune response in many viral infections. For many years, it has been observed that CD8(+) cells were present in large numbers in the liver of patients with chronic HCV (1), but it was unknown whether these cells represented virus-specific immune responses. In order to understand the potential role of these CD8(+) lymphocytes in the disease course, it is first necessary to define the functional characteristics of the cells, including a precise definition of the epitopes, which are recognized by these CD8(+) lymphocytes.
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