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Atrial natriuretic factor in patients with right ventricular infarction
B D Robalino1, R W Petrella, F Y Jubran
1Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195.
Journal of the American College of Cardiology
|March 1, 1990
Summary
Right ventricular infarction is linked to elevated atrial natriuretic factor, a key hormone in the body's response. This suggests atrial natriuretic factor plays a role in the right ventricular infarct syndrome.
Area of Science:
- Cardiology
- Endocrinology
- Physiology
Background:
- Right ventricular infarction (RVI) is a serious complication of acute myocardial infarction.
- The role of atrial natriuretic factor (ANF) in RVI pathophysiology is not fully understood.
Purpose of the Study:
- To investigate the association between ANF levels and RVI in patients with acute inferior myocardial infarction.
- To explore the potential pathophysiologic role of ANF in the right ventricular infarct syndrome.
Main Methods:
- Serial plasma ANF measurements were performed in 21 patients with acute inferior myocardial infarction.
- Patients were divided into two groups: 8 with RVI (Group I) and 13 without RVI (Group II).
- Included enzymatic, ECG, echocardiographic, coronary arteriographic, and hemodynamic assessments.
Main Results:
- Group I patients exhibited significantly lower mean arterial pressure and higher right atrial pressures compared to Group II.
- Elevated plasma ANF levels were observed in Group I on days 1, 3, and 7 post-infarction compared to Group II.
- Higher incidence of prolonged hypotension and right ventricular dysfunction was noted in Group I.
Conclusions:
- Elevated ANF is part of the neurohumoral response to RVI.
- These findings support the hypothesis that ANF plays a pathophysiologic role in the right ventricular infarct syndrome.