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Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

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Related Experiment Video

Updated: Jun 3, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Engineering Nanocarriers for siRNA Delivery.

Shawn J Tan1, Pichamon Kiatwuthinon, Young Hoon Roh

  • 1Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|March 5, 2011
PubMed
Summary
This summary is machine-generated.

RNA interference (RNAi) offers gene therapy potential. This review guides the engineering of clinically-relevant nanocarriers for efficient and targeted small interfering RNA (siRNA) delivery to treat diseases.

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Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
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Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

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Last Updated: Jun 3, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery
08:53

Synthesis, Functionalization, and Characterization of Fusogenic Porous Silicon Nanoparticles for Oligonucleotide Delivery

Published on: April 16, 2019

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Biology

Background:

  • RNA interference (RNAi) has renewed interest in gene therapy.
  • Current nanocarriers for RNAi face challenges in clinical relevance, biocompatibility, and efficiency.
  • Targeted delivery of therapeutic RNA remains a significant hurdle.

Purpose of the Study:

  • To review nanomaterials and functional add-ons for nanocarrier development.
  • To provide a guide for engineering effective nanocarriers for small interfering RNA (siRNA) delivery.
  • To address the need for clinically-relevant and disease-specific nanocarrier solutions.

Main Methods:

  • Comprehensive literature survey of nanomaterials for drug delivery.
  • Analysis of functionalization strategies for enhanced nanocarrier performance.
  • Evaluation of nanocarrier properties for siRNA encapsulation and release.

Main Results:

  • Diverse range of nanomaterials applicable to siRNA delivery identified.
  • Functionalization approaches offer improved targeting and biocompatibility.
  • Key parameters for engineering efficient siRNA-loaded nanocarriers outlined.

Conclusions:

  • Nanocarrier engineering is crucial for advancing RNAi-based gene therapy.
  • Tailored nanocarriers can overcome current delivery limitations.
  • Further development is needed for clinically translatable siRNA delivery systems.