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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Related Experiment Video

Updated: Jun 3, 2026

Microfluidic Genipin Deposition Technique for Extended Culture of Micropatterned Vascular Muscular Thin Films

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Published on: June 26, 2015

[Progress in research on LiquiChip technology in biomedical engineering].

Guohua Hui¹, Zikai Zhao

¹College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China. ghui@zjgsu.edu.cn

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi

|March 8, 2011

Summary

The LiquiChip technique, a novel BioChip method, uses fluorescent beads in liquid systems for high-throughput biomolecule detection. This advanced biosensor offers superior sensitivity and accuracy for various biomedical applications.

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Last Updated: Jun 3, 2026

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Area of Science:

Biotechnology
Biosensor Technology
Molecular Diagnostics

Context:

Conventional biochips face limitations in throughput and sensitivity.
The need for advanced methods in biomolecule detection is growing.
The biomedical engineering field requires precise and efficient analytical tools.

Purpose:

To introduce and describe the LiquiChip technique as a novel BioChip method.
To highlight the advantages of LiquiChip over traditional biochip technologies.
To showcase the diverse applications of LiquiChip in biological and environmental analysis.

Summary:

LiquiChip technique utilizes fluorescent polystyrene beads as carriers for probes in a liquid system.
It enables high-throughput, high-sensitivity, and high-accuracy detection of biomacromolecules.
Applications include DNA detection, immunoassays, cytokine and hormone assays, and environmental monitoring.

Impact:

LiquiChip offers significant improvements over conventional biochips, including enhanced throughput, sensitivity, accuracy, repeatability, and linear range.
The technique is widely adopted in the biomedical engineering field.
Facilitates advancements in diagnostics, research, and environmental analysis through efficient biomolecule detection.