Related Experiment Video
Updated: Jun 3, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Thrombolysis with reteplase for recurrent mechanical heartvalve thrombosis
Naveed Akhtar1, Yasser Jalil Khan, Waqas Ahmed
1Department of Cardiology, Shifa College of Medicine, Islamabad.
Abstract:
Thrombotic occlusion of a prosthetic valve continues to be an uncommon but life threatening complication of mechanical valves. However, recurrent prosthetic valve thrombosis is yet a rare complication. Urokinase and tissue plasminogen activator (tPA) have previously been used with success in cases of recurrent thrombus formation and/or failure of streptokinaSe treatment. We report the first three cases of recurrent prosthetic mitral valve thrombosis in Pakistan which were treated with Reteplase that resulted in re-establishment of adequate blood flow across the valve with reduction of mean gradient to normal.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Rheumatic Heart Disease III: Medical Management
Mitral Regurgitation III: Medical Management
Mitral Stenosis III: Medical Management
Endocarditis III: Medical Management
