Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acid Mine Drainage01:19

Acid Mine Drainage

Mining activities that disturb sulfide-rich rocks, particularly those containing pyrite (FeS₂), initiate a cascade of geochemical and microbiological processes with serious environmental implications. When exposed to air and water, pyrite undergoes oxidation, releasing sulfate, ultimately forming sulfuric acid and mobilizing heavy metals into surrounding water systems. This phenomenon, known as acid mine drainage (AMD), results in low pH waters laden with toxic elements that threaten aquatic...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Drug Elimination by Renal Route: Tubular Reabsorption01:22

Drug Elimination by Renal Route: Tubular Reabsorption

During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. However, the majority of drugs are either weak acids or weak bases, and their ionization level is dependent on pH. By altering the pH of urine, the...
Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transfusion After Femur Fracture in a Cave.

Wilderness & environmental medicine·2025
Same author

Axonal Guillain-Barré Syndrome After Leptospirosis Contracted in a Cave or While Packrafting-A Case Report.

Wilderness & environmental medicine·2025
Same author

Proposed Standardization of Protocols for Carbon Monoxide Studies: In Response to A Field Study of Carbon Monoxide Levels in Snow Caves During Short-Term Stove Use by Nielsen and Karlsen.

Wilderness & environmental medicine·2024
Same author

Suspension syndrome: a scoping review and recommendations from the International Commission for Mountain Emergency Medicine (ICAR MEDCOM).

Scandinavian journal of trauma, resuscitation and emergency medicine·2023
Same author

Psychological First Aid for Wilderness Trauma: Interventions for Expedition or Search and Rescue Team Members.

Wilderness & environmental medicine·2023
Same author

Tibial Plateau Fracture After Attack by an Escaped Goat.

Wilderness & environmental medicine·2022

Related Experiment Video

Updated: Jun 3, 2026

Use of MALDI-TOF Mass Spectrometry and a Custom Database to Characterize Bacteria Indigenous to a Unique Cave Environment (Kartchner Caverns, AZ, USA)
11:09

Use of MALDI-TOF Mass Spectrometry and a Custom Database to Characterize Bacteria Indigenous to a Unique Cave Environment (Kartchner Caverns, AZ, USA)

Published on: January 2, 2015

Rhabdomyolysis after prolonged suspension in a cave.

David R Wharton1, Roger B Mortimer

  • 1Erlanger Medical Center, Division of Emergency Medicine, University of Tennessee, Chattanooga, TN, USA.

Wilderness & Environmental Medicine
|March 8, 2011
PubMed
Summary

Immediate rescue and intravenous fluids are crucial for individuals experiencing suspension trauma. Prompt treatment can prevent severe complications like rhabdomyolysis and kidney failure.

More Related Videos

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Purification of the Sarco-Endoplasmic Reticulum Ca2+-ATPase from Rabbit Muscle
08:37

Purification of the Sarco-Endoplasmic Reticulum Ca2+-ATPase from Rabbit Muscle

Published on: March 21, 2025

Related Experiment Videos

Last Updated: Jun 3, 2026

Use of MALDI-TOF Mass Spectrometry and a Custom Database to Characterize Bacteria Indigenous to a Unique Cave Environment (Kartchner Caverns, AZ, USA)
11:09

Use of MALDI-TOF Mass Spectrometry and a Custom Database to Characterize Bacteria Indigenous to a Unique Cave Environment (Kartchner Caverns, AZ, USA)

Published on: January 2, 2015

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats
08:47

Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

Published on: November 8, 2018

Purification of the Sarco-Endoplasmic Reticulum Ca2+-ATPase from Rabbit Muscle
08:37

Purification of the Sarco-Endoplasmic Reticulum Ca2+-ATPase from Rabbit Muscle

Published on: March 21, 2025

Area of Science:

  • Emergency Medicine
  • Trauma Care
  • Environmental Health

Background:

  • Suspension trauma, also known as harness atau positional asphyxia, is a serious risk during activities like caving or climbing.
  • It occurs when a person is passively suspended for extended periods, leading to physiological distress.
  • Early recognition and intervention are vital for patient outcomes.

Observation:

  • A 29-year-old male experienced prolonged suspension (4+ hours) during a caving incident.
  • Upon rescue, he presented with lower limb weakness and sensory deficits, accompanied by shivering.
  • Initial field treatment included calcium chloride, normal saline, and bicarbonate.

Findings:

  • Hospitalization revealed elevated creatine phosphokinase (CPK) levels, indicative of muscle damage.
  • Intravenous fluid administration led to the resolution of elevated CPK levels.
  • The case highlights the potential for suspension trauma to cause both early syncope and late-onset rhabdomyolysis.

Implications:

  • Immediate rescue of passively suspended individuals is paramount to prevent severe outcomes.
  • Prompt administration of intravenous fluids is essential for mitigating the risk of rhabdomyolysis and subsequent renal failure.
  • This case underscores the importance of preparedness and rapid response protocols in activities with suspension risks.