Related Experiment Video
Updated: Jun 3, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
Published on: September 13, 2018
Hippo signalling: liver size regulation and beyond.
1Inserm U757, université Paris-sud, bâtiment 443, 91405 Orsay, France. thierry.tordjmann@u-psud.fr
Clinics and Research in Hepatology and Gastroenterology
|March 8, 2011
Summary
The Hippo signalling pathway regulates organ size in mammals. This pathway is crucial for liver homeostasis, controlling cell proliferation and apoptosis, and may play a key role in liver cancer.
Area of Science:
- Cell Biology
- Molecular Biology
- Developmental Biology
Background:
- The Hippo signalling pathway, initially discovered in Drosophila, is conserved in mammals.
- This pathway is essential for regulating organ size and tissue homeostasis.
Purpose of the Study:
- To investigate the role of the Hippo signalling pathway in mammalian liver tissue homeostasis.
- To explore the connection between Hippo signalling and liver carcinogenesis.
Main Methods:
- Review of recent studies on Hippo signalling in mammals.
- Analysis of Hippo pathway's regulation of cellular proliferation and apoptosis in the liver.
Main Results:
- The Hippo signalling pathway is critical for maintaining liver tissue homeostasis.
- It regulates key processes including cellular proliferation and apoptosis in the liver.
Conclusions:
- Hippo signalling is a vital component of liver tissue homeostasis.
- Dysregulation of the Hippo pathway may contribute to liver carcinogenesis, highlighting its potential as a therapeutic target.
Related Concept Videos
01:30Liver Physiology
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
02:33Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
02:33Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
01:30Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
01:58Cell Specific Gene Expression
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...