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4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid
F J Van Kuijk1, L L Holte, E A Dratz
1Chemistry Department, Montana State University, Bozeman 59717.
Biochimica Et Biophysica Acta
|March 12, 1990
Abstract:
4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n - 6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.