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Relationship between RegIV gene expression to outcomes in colorectal cancer
Masakatsu Numata1, Takashi Oshima, Kazue Yoshihara
1Gastroenterological Center, Yokohama City University Medical Center, Minami-ku, Yokohama-shi, Kanagawa-ken, Japan.
Background:
Regenerating islet-derived family members (Reg) are superfamily of calcium-dependant lectins that are expressed in the proximal gastrointestinal tract and ectopically at other sites in the setting of tissue injury. The regenerating islet-derived family member 4 (RegIV) gene has been reported in various cancers, associating with diverse functions. This study examined the relation of the relative expression of RegIV gene to clinicopathological factors and outcomes in patients with colorectal cancer (CRC).
Methods:
We studied surgical specimens of cancer tissue and adjacent normal mucosa obtained from 202 patients with untreated CRC. The relative expression levels of RegIV mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction.
Results:
RegIV gene expression was higher in cancer tissue than in adjacent normal mucosa. The multivariate analysis of clinicopathological factors for 5-year overall survival showed a higher level of RegIV gene expression was a significant independent predictor. Overall survival at 5 years differed significantly between patients with high RegIV gene expression and those with low expression.
Conclusions:
Overexpression of the RegIV gene is considered a useful independent predictor of outcomes in patients with CRC.
Insights
Overexpression of the regenerating islet-derived family member 4 (RegIV) gene in colorectal cancer (CRC) predicts patient outcomes. Higher RegIV gene expression in tumors correlates with poorer survival, making it a significant independent prognostic marker.
Area of Science:
- Molecular biology
- Oncology
- Gastroenterology
Background:
- Regenerating islet-derived (Reg) proteins are calcium-dependent lectins involved in tissue repair.
- Reg family member 4 (RegIV) is implicated in various cancers.
- This study investigates RegIV gene expression in colorectal cancer (CRC).
Purpose of the Study:
- To examine the relationship between RegIV gene expression and clinicopathological factors in CRC patients.
- To assess RegIV gene expression as a predictor of patient outcomes in CRC.
Main Methods:
- Quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) was used.
- Surgical specimens of tumor tissue and adjacent normal mucosa from 202 untreated CRC patients were analyzed.
- Relative RegIV mRNA expression levels were measured in both cancer and normal tissues.
Main Results:
- RegIV gene expression was significantly higher in colorectal cancer tissues compared to adjacent normal mucosa.
- Elevated RegIV gene expression emerged as a significant independent predictor of 5-year overall survival in multivariate analysis.
- Patients with high RegIV gene expression demonstrated significantly lower 5-year overall survival rates compared to those with low expression.
Conclusions:
- Overexpression of the RegIV gene serves as a valuable independent prognostic indicator for patients with colorectal cancer.
- RegIV gene expression levels can help predict outcomes in CRC patients.
