Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different Relationships between F<sub>E</sub>NO and COPD Characteristics in Smokers and Ex-Smokers.

COPD·2019
Same author

Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects.

Journal of breath research·2017
Same author

Extended nitric oxide analysis may improve personalized anti-inflammatory treatment in asthmatic children with intermediate F(E)NO50.

Journal of breath research·2015
Same author

Allergen extract vs. component sensitization and airway inflammation, responsiveness and new-onset respiratory disease.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
Same author

A practical approach to the theoretical models to calculate NO parameters of the respiratory system.

Journal of breath research·2014
Same author

Methods of NO detection in exhaled breath.

Journal of breath research·2013

Related Experiment Video

Updated: Jun 3, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Extended NO analysis in asthma.

M Högman1, P Meriläinen

  • 1Department of Medical Cell Biology, Uppsala University, Sweden. Center for Research and Development, Uppsala University, County Council of Gävleborg, Sweden.

Journal of Breath Research
|March 9, 2011
PubMed
Summary
This summary is machine-generated.

Flow dependence of exhaled nitric oxide (NO) allows lung NO production modeling. Asthma shows increased NO flux, airway diffusing capacity, and wall concentrations, highlighting airway diffusing capacity for new asthma drug testing.

More Related Videos

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Related Experiment Videos

Last Updated: Jun 3, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Area of Science:

  • Respiratory Medicine
  • Pulmonary Physiology
  • Biomedical Engineering

Background:

  • Nitric oxide (NO) production in the lung is influenced by airflow.
  • Modeling NO production is crucial for understanding respiratory conditions.

Purpose of the Study:

  • To investigate the role of exhaled nitric oxide (NO) in modeling lung NO production.
  • To characterize NO parameters in asthma patients using linear and nonlinear models.

Main Methods:

  • Utilized flow-dependent models of exhaled NO to assess NO production.
  • Applied linear and nonlinear modeling to differentiate airway and alveolar NO contributions.
  • Analyzed parameters like maximal flux, alveolar concentration, airway diffusing capacity, and airway wall NO concentrations.

Main Results:

  • Asthma patients exhibit increased NO flux, airway diffusing capacity, and airway wall NO concentrations.
  • Alveolar NO concentrations are similar to healthy individuals, except in severe asthma.
  • Inhaled corticosteroids reduce airway wall NO concentrations, while oral prednisone affects alveolar concentration.

Conclusions:

  • Airway diffusing capacity is a key parameter for asthma drug testing and treatment strategies.
  • Exhaled NO analysis is a valuable tool for characterizing asthma in all age groups.
  • Standardization of NO modeling techniques and flow rates is essential for robust clinical application.