Related Experiment Video
Updated: Jan 21, 2026
14:21
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Published on: August 6, 2013
18.8K
Different Relationships between FENO and COPD Characteristics in Smokers and Ex-Smokers
M Högman1, A Thornadtsson1,2, K Bröms2,3
1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University , Uppsala , Sweden.
COPD
|July 31, 2019
Summary
Exhaled nitric oxide (FENO) levels are lower in current smokers with COPD. FENO is linked to inflammation and lung function in ex-smokers, but less so in current smokers, suggesting limited clinical utility in active smokers.
Area of Science:
- Pulmonary Medicine
- Respiratory Inflammation
- Biomarker Research
Background:
- Exhaled nitric oxide (FENO) indicates type-2 airway inflammation in asthma.
- Clinical utility of FENO in COPD is unclear, particularly in smokers and ex-smokers who exhibit lower FENO levels.
Purpose of the Study:
- To investigate the relationship between FENO and COPD characteristics in current smokers and ex-smokers.
- To assess FENO's association with blood cell counts, lung function, and medication use in COPD patients.
Main Methods:
- Studied 533 stable COPD patients (58% female).
- Measured FENO50, blood cell counts, IgE sensitization, and lung function.
- Utilized medication reconciliation to determine drug usage.
Main Results:
- Smokers (n=150) had lower FENO50 (9 ppb) than ex-smokers (n=383) (15 ppb).
- FENO50 correlated with eosinophils and lung function (FEV1) in ex-smokers, but not in smokers.
- Ex-smokers on inhaled corticosteroids (ICS) showed lower FENO50 compared to untreated ex-smokers.
Conclusions:
- FENO is associated with eosinophilic inflammation and ICS use in ex-smoking COPD patients.
- The value of FENO as an inflammatory marker appears limited in current smokers with COPD.
- The link between low FENO and reduced lung function in COPD warrants further investigation.
More Related Videos
Related Concept Videos
02:12Relationship Formation
45.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
45.2K
01:20COPD: Pathogenesis and Clinical Features
1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
01:26COPD: Management Using Bronchodilators and Corticosteroids
748
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
748
01:23Characteristics of Life
256.6K
Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
256.6K
01:28Ending Relationships
174
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
174
01:27Relationship Growth
209
Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
209