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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

The role of echocardiography in predicting responders to cardiac resynchronization therapy

Yoshihiro Seo1, Hiroshi Ito, Satoshi Nakatani

  • 1Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|March 9, 2011
PubMed

Insights

Echocardiography alone has limited ability to predict cardiac resynchronization therapy (CRT) responders. However, a combined dyssynchrony measure and left bundle branch block predict CRT success and improved clinical outcomes.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Clinical Research

Background:

  • Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
  • Identifying CRT responders is crucial for optimizing patient outcomes.
  • Echocardiography is a key imaging modality in cardiology.

Purpose of the Study:

  • To assess the ability of echocardiographic parameters to identify CRT volume responders.
  • To investigate the relationship between these echocardiographic parameters and clinical outcomes.
  • To determine predictors of CRT success.

Main Methods:

  • A multicenter prospective cohort study involving 217 patients.
  • Defined CRT responders as ≥15% reduction in left ventricular end-systolic volume at 6 months.
  • Evaluated seven echocardiographic dyssynchrony parameters and clinical endpoints (death or hospitalization).

Main Results:

  • 63% of patients were classified as volume responders, with significantly fewer adverse events.
  • No single echocardiographic parameter reliably detected responders.
  • A combined dyssynchrony measurement (septum-LV free wall M-mode/TDI) and left bundle branch block independently predicted responders and improved outcomes.

Conclusions:

  • Echocardiographic parameters alone lack significant power to independently detect CRT responders.
  • Left bundle branch block is a strong predictor of CRT response and clinical benefit.
Abstract

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