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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Intracellular Movement of Viruses and Bacteria01:10

Intracellular Movement of Viruses and Bacteria

Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a virus that...
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
DNA Bacteriophages01:26

DNA Bacteriophages

Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
CRISPR and crRNAs02:53

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...

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Updated: Jun 3, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

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Published on: May 8, 2015

Controlling forces and pathways in self-assembly using viruses and DNA.

Jung-Won Keum1, Adam P Hathorne, Harry Bermudez

  • 1Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|March 9, 2011
PubMed
Summary

Viruses and DNA can self-assemble into nanoscale structures, enabling diverse applications. This review explores the interactions, experimental control, and recent advances in utilizing these self-assembling nanostructures.

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Area of Science:

  • Nanotechnology
  • Biophysics
  • Materials Science

Background:

  • Viruses and DNA exhibit inherent self-assembly properties in solution.
  • These properties are foundational for nanoscale applications and advanced materials.

Purpose of the Study:

  • To review interactions governing virus and DNA self-assembly.
  • To discuss experimental strategies for controlling self-assembly processes.
  • To highlight recent applications of self-assembling nanostructures.

Main Methods:

  • Review of scientific literature on molecular interactions.
  • Analysis of experimental techniques for controlling self-assembly.
  • Case studies of recent nanostructure applications.

Main Results:

  • Identified key interactions driving self-assembly of viral and DNA structures.
  • Outlined methods for achieving spatial and temporal control over self-assembly.
  • Showcased innovative uses of these nanostructures in various fields.

Conclusions:

  • Self-assembly of viruses and DNA offers significant potential for nanoscale engineering.
  • Precise control over self-assembly unlocks new experimental possibilities.
  • Continued research promises further breakthroughs in nanostructure applications.