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Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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Related Experiment Video

Updated: Jun 3, 2026

Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection
06:00

Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection

Published on: December 30, 2025

Serum YKL-40 levels in acute appendicitis.

M Koc1, B Zulfikaroglu, F Kemal Isman

  • 1Fifth Department of General Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey. mesuttez@yahoo.com

Bratislavske Lekarske Listy
|March 10, 2011
PubMed
Summary

Serum YKL-40 levels were significantly higher in patients with acute appendicitis. This suggests YKL-40 may aid in diagnosing this common abdominal emergency, though further research is needed.

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Area of Science:

  • Biochemistry
  • Medical Diagnostics
  • Surgical Emergencies

Background:

  • Acute appendicitis is a frequent surgical emergency with challenging clinical diagnosis.
  • Delayed diagnosis increases risks of perforation and complications.
  • Preoperative assessment is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the diagnostic utility of serum YKL-40 levels in patients with suspected acute appendicitis.
  • To determine if YKL-40 can differentiate between acute appendicitis and normal appendix cases.

Main Methods:

  • A study involving 34 patients diagnosed with acute appendicitis and undergoing appendectomy.
  • Patients were categorized into normal appendix (n=10) and acute appendicitis (n=24) groups.
  • Serum YKL-40 levels were quantified using a commercial ELISA kit.

Main Results:

  • Significantly elevated serum YKL-40 levels were observed in the acute appendicitis group (66.4 ± 13.2 ng/mL) compared to the normal appendix group (41.6 ± 11.6 ng/mL).
  • The area under the receiver operating characteristic curve (AUC) for YKL-40 was 0.926, indicating high diagnostic accuracy (p < 0.001).

Conclusions:

  • Serum YKL-40 shows potential as a biomarker for diagnosing acute appendicitis.
  • Larger studies are warranted to validate these findings and confirm YKL-40's clinical utility.