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Updated: Jun 3, 2026

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Base-mediated intermolecular sp2 C-H bond arylation via benzyne intermediates

Thanh Truong1, Olafs Daugulis

  • 1Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.

Journal of the American Chemical Society
|March 10, 2011
PubMed
Summary

A new transition-metal-free method enables arylation of C-H bonds using aryl chlorides and fluorides. This efficient process generates aryne intermediates for selective coupling, advancing organic synthesis.

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