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Interferon-γ modulates intestinal epithelial cell function in-vitro through a TGFβ-dependent mechanism

Peter Hoffmann1, Andreas Sturm, Jürgen Stein

  • 1Department of Internal Medicine I, Kliniken Essen Mitte, Germany.

Regulatory Peptides
|March 10, 2011
PubMed
Summary

Interferon γ (IFNγ) enhances intestinal epithelial cell migration and inhibits proliferation, potentially aiding wound healing. These effects are mediated by transforming growth factor β (TGFβ), suggesting a role for IFNγ in maintaining intestinal integrity.

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