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Related Experiment Video

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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
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Recent advances in Tourette syndrome.

Michael Bloch1, Matthew State, Christopher Pittenger

  • 1Department of Psychiatry and the Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA.

Current Opinion in Neurology
|March 10, 2011
PubMed
Summary

Recent Tourette syndrome research highlights the basal ganglia's role in tics and emphasizes both behavioral and drug treatments. Genetic studies also reveal shared risks across diagnoses.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Tourette syndrome (TS) is a complex neurodevelopmental disorder.
  • The basal ganglia have long been hypothesized to play a central role in tic generation.

Purpose of the Study:

  • To review recent literature on the neurobiology, genetics, and treatment of Tourette syndrome.
  • To synthesize current findings and their implications for understanding and managing TS.

Main Methods:

  • Literature review of recent studies on Tourette syndrome.
  • Analysis of neuropathological, genetic, and treatment research.

Main Results:

  • Neuropathological and genetic findings reinforce the basal ganglia's involvement in TS.
  • Genetic research highlights the significance of rare variations and shared risks with other neuropsychiatric conditions.
  • Treatment studies confirm the efficacy of both cognitive-behavioral therapy and pharmacological interventions for tic disorders.

Conclusions:

  • Recent findings generate new hypotheses about the molecular and cellular mechanisms of TS.
  • These insights offer novel approaches to treatment strategies.
  • Non-pharmacological treatments are safe and effective, though new medications are also needed.