Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Acute Pancreatitis II: Pathophysiology

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Helicobacter pylori eradication rate following first line non-bismuth quadruple therapy regimen in Tunisian patients: the HPERAD study.

BMC infectious diseases·2025

Same author

Colonic strictures in Crohn's disease: a non-surgical survival.

Future science OA·2025

Same author

Abnormal expression of oxylipins and related synthesizing/signaling pathways in inflammatory bowel diseases.

Prostaglandins, leukotrienes, and essential fatty acids·2024

Same author

Eradication of <i>Helicobacter pylori</i>: a prospective comparative randomized trial of standard versus optimized quadruple therapy.

Future science OA·2024

Same author

Intestinal T-cell lymphoma not otherwise specified: a case report and literature review.

Future science OA·2024

Same author

Overlap syndrome of seronegative primary biliary cholangitis and small duct primary sclerosing cholangitis: a first case report and literature review.

Future science OA·2024

Search research articles

Related Experiment Video

Updated: Jun 3, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

[Autoimmune pancreatitis : A systematic review].

Lamia Kallel¹, Narjess Naija, Jalel Boubaker

¹Service de Gastroentérologie A. Hôpital la Rabta, Tunis, Tunisie.

La Tunisie Medicale

|March 10, 2011

Summary

Autoimmune pancreatitis, a systemic disorder, presents with characteristic IgG4-positive plasma cells and fibrosis. Early diagnosis and steroid treatment are crucial for managing this rare condition.

More Related Videos

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Related Experiment Videos

Last Updated: Jun 3, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

Area of Science:

Gastroenterology
Immunology
Pathology

Background:

Autoimmune pancreatitis (AIP) is a distinct subtype of chronic pancreatitis.
It is increasingly recognized as a systemic autoimmune condition.

Purpose of the Study:

To elucidate the etiopathogenic, histologic, morphologic, clinical, and therapeutic aspects of AIP.
To review existing literature on AIP.

Main Methods:

Comprehensive literature review of studies published before August 2008.
Analysis of diagnostic criteria and treatment responses.

Main Results:

AIP is a systemic disease affecting multiple organs (bile duct, retroperitoneum, kidney, salivary glands).
Histological hallmarks include lymphoplasmacytic infiltration with IgG4-positive plasma cells and fibrosis.
It predominantly affects elderly men, can mimic pancreatic cancer, and responds well to steroids.

Conclusions:

Interest in AIP has surged since its identification, leading to a clearer understanding of its clinical features.
Diagnostic criteria have been established to aid in diagnosis and prevent unnecessary surgeries.