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Masked hypertension unfavourably affects haemostasis parameters
D P Papadopoulos1, C Thomopoulos, I Mourouzis
1ESH Excellent Center of Hypertension, Laiko Univesity Hospital, Athens, Greece. jimpapdoc@yahoo.com
Blood Pressure
|March 11, 2011
Summary
Masked hypertension (MH) is linked to higher levels of fibrinogen, thrombomodulin, plasminogen activator inhibitor-1, and tissue plasminogen activator. These haemostasis markers may indicate increased cardiovascular risk in individuals with MH.
Area of Science:
- Cardiovascular Medicine
- Haemostasis Research
- Hypertension Studies
Background:
- Masked hypertension (MH) is an emerging cardiovascular disease predictor.
- Understanding the impact of MH on haemostasis is crucial for risk assessment.
Purpose of the Study:
- To investigate the association between masked hypertension and haemostasis parameters.
- To compare haemostasis profiles in individuals with MH versus healthy normotensives.
Main Methods:
- 130 healthy subjects underwent 24-hour ambulatory blood pressure monitoring (ABPM).
- Participants were categorized into masked hypertension (Group A) and normotensive (Group B) groups.
- Plasma levels of fibrinogen, thrombomodulin (TM), plasminogen activator inhibitor 1 antigen (PAI-1Ag), and tissue plasminogen activator antigen (tPA-Ag) were measured.
Main Results:
- Individuals with masked hypertension exhibited significantly elevated levels of PAI-1Ag, tPA-Ag, fibrinogen, and TM compared to normotensive controls.
- These findings indicate a prothrombotic state associated with masked hypertension.
Conclusions:
- Masked hypertension is associated with significantly higher plasma levels of key haemostasis factors.
- These haemostatic alterations in MH may have prognostic implications for future cardiovascular events, warranting further research.
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