Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pedigree Analysis01:35

Pedigree Analysis

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances and outcomes in head and neck surgery.

The Journal of laryngology and otology·2026
Same author

Rewriting the playbook: outcomes, evidence and the surgeons of tomorrow - CORRIGENDUM.

The Journal of laryngology and otology·2026
Same author

Under pressure: workforce, workload.

The Journal of laryngology and otology·2026
Same author

Workforce planning for ENT services in the UK: challenges and future directions.

The Journal of laryngology and otology·2026
Same author

Navigating risk, timing and intervention in Otolaryngology.

The Journal of laryngology and otology·2026
Same author

A new four-arm within-study comparison: Design, implementation, and data.

Observational studies·2026
Same journal

Preface.

Advances in oto-rhino-laryngology·2020
Same journal

Future Advances in Neurolaryngology.

Advances in oto-rhino-laryngology·2020
Same journal

Structure, Function and Insertion of the Human Vocal Folds.

Advances in oto-rhino-laryngology·2020
Same journal

Laryngeal Reinnervation: The History and Where We Stand Now.

Advances in oto-rhino-laryngology·2020
Same journal

Neuromuscular Disease Affecting the Larynx.

Advances in oto-rhino-laryngology·2020
Same journal

Objective Measures of Stroboscopy and High-Speed Video.

Advances in oto-rhino-laryngology·2020
See all related articles

Related Experiment Videos

Paediatric Baha.

Ann-Louise McDermott, Patrick Sheehan

    Advances in Oto-Rhino-Laryngology
    |March 11, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Bone-anchored hearing aids (Baha) offer effective aural rehabilitation for children, improving hearing and quality of life. Careful patient selection and a multidisciplinary approach ensure successful outcomes with rare serious complications.

    Related Experiment Videos

    Area of Science:

    • Otolaryngology
    • Pediatric Audiology
    • Biomedical Engineering

    Background:

    • Bone-anchored hearing aids (Baha) are a recognized solution for pediatric hearing loss.
    • Evidence supports Baha's efficacy in improving audiological outcomes and quality of life in children.
    • There's a global rise in pediatric Baha service centers.

    Purpose of the Study:

    • To review the current status of Baha for pediatric aural rehabilitation.
    • To discuss evolving indications and surgical considerations for pediatric Baha.
    • To highlight challenges and best practices in managing children with Baha.

    Main Methods:

    • Literature review of Baha in pediatric populations.
    • Analysis of audiological and quality of life outcomes.
    • Discussion of surgical techniques, timing, and complication rates.

    Main Results:

    • Baha demonstrates significant benefits for children's hearing and quality of life.
    • Pediatric Baha presents unique challenges including complex medical and social factors.
    • Surgical techniques and timing vary, but serious complications remain rare.

    Conclusions:

    • Baha is a valuable tool for pediatric hearing rehabilitation.
    • Addressing pediatric-specific challenges is crucial for successful Baha implantation.
    • Careful patient selection and a multidisciplinary team are key to optimal outcomes.