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Down's syndrome and coeliac disease.

J A Dias1, J Walker-Smith

  • 1Department of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London, United Kingdom.

Journal of Pediatric Gastroenterology and Nutrition
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study found a higher incidence of Down syndrome in patients with coeliac disease. This suggests a potential link between Down syndrome and coeliac disease, warranting consideration in clinical evaluations.

Area of Science:

  • Medical Science
  • Genetics
  • Gastroenterology

Background:

  • Congenital abnormalities and gastrointestinal diseases share known associations.
  • The link between Down syndrome and coeliac disease is occasionally noted but not definitively established.

Observation:

  • A review of 190 coeliac disease patients diagnosed between 1960-1985 was conducted.
  • Maternal age was below the typical threshold for increased Down syndrome incidence.

Findings:

  • An increased incidence of Down syndrome was observed in coeliac disease patients compared to the general population.
  • This suggests a potential etiological link between Down syndrome and coeliac disease.

Implications:

  • Clinicians should consider the possibility of coeliac disease in children diagnosed with Down syndrome.

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  • Further research is warranted to elucidate the relationship between these two conditions.