Related Experiment Video
Updated: Aug 12, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Down's syndrome and coeliac disease
1Department of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London, United Kingdom.
Abstract:
The association of congenital abnormalities and gastrointestinal tract diseases has been described. The coincidence of Down's syndrome and coeliac disease has been occasionally reported, but a clear relation is not definitely established. Reviewing 190 patients with coeliac disease diagnosed at Queen Elizabeth Hospital, London, from 1960 to 1985 an increased incidence of Down's syndrome compared to the natural incidence of this abnormality in the general population was found. The age of the mothers was well below that where a reverse in the incidence of Down's syndrome is expected, and it appears therefore that this anomaly and coeliac disease may be linked. This possibility should be bourne in mind when evaluating children with Down's syndrome and gastrointestinal symptoms.
Related Concept Videos
Meiosis I
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Inborn Errors of Metabolism
Diabetes Mellitus: Type 2 and Gestational
Inflammatory Bowel Disease III: Crohn's Disease

