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Two distinct cellular proteins interact with the EIa-responsive element of an adenovirus early promoter
P Jansen-Durr1, M Wintzerith, B Reimund
1Laboratoire de Génétique Moléculaire des Eucaryotes du Centre National de la Recherche Scientifique, Faculté de Médecine, Strasbourg, France.
Journal of Virology
|May 1, 1990
Abstract:
EIa-dependent transactivation of the adenovirus EIIa early (EIIaE) promoter is correlated with the activation of the cellular transcription factor E2F. In this study we identified a cellular protein, C alpha, that is distinct from E2F and that binds two sites in the EIIaE promoter, one of which overlaps with the proximal E2F binding site of the EIIaE promoter. The possible involvement of C alpha in the EIa responsiveness of this promoter is discussed.