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Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome

M Zutt1, U Krüger, A Rosenberger

  • 1Department of Dermatology, Venereology and Allergology, University of Göttingen, Göttingen, Germany. mzutt@gwdg.de

Journal of the European Academy of Dermatology and Venereology : JEADV
|March 12, 2011
PubMed

Insights

Thrombophilia, a tendency to clot, is more common in patients with chronic venous leg ulcers (CVU) and post-thrombotic syndrome (PTS). This suggests thrombophilia may play a role in CVU development.

Area of Science:

  • Vascular Medicine
  • Dermatology
  • Hematology

Background:

  • Chronic venous leg ulcers (CVU) represent a significant health burden and healthcare cost.
  • The complex pathophysiology of CVU is not fully understood, lacking reliable pathogenic or prognostic markers.

Purpose of the Study:

  • Investigate the role of thrombophilia in patients with CVU.
  • Stratify patients based on the presence or absence of post-thrombotic syndrome (PTS).

Main Methods:

  • Studied 310 patients with active CVU (CEAP 6).
  • Grouped patients into PTS+ and PTS- categories using duplex scan and/or phlebography.
  • Assessed multiple thrombophilia parameters.

Main Results:

  • Protein S deficiency and factor V Leiden mutation were more prevalent in the PTS+ group.
  • Both PTS+ and PTS- groups showed high prevalences of various thrombophilias.
  • Identified thrombophilias include antithrombin deficiency, protein C deficiency, protein S deficiency, activated protein C resistance, factor V mutation, and elevated homocysteine.

Conclusions:

  • Thrombophilia may contribute to the pathogenesis of CVU.
  • Potential mechanism involves the induction of microcirculatory dysregulations.
Abstract

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