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Superior sagittal sinus thrombosis in a patient with protein S deficiency
1Department of Psychiatry, Tulane University School of Medicine, New Orleans, Louisiana.
Insights
This case highlights protein S deficiency as a cause of recurrent cerebral thrombosis. Long-term anticoagulant therapy may prevent future thrombotic events in affected individuals.
Area of Science:
- Neurology
- Hematology
- Genetics
Background:
- Recurrent thrombotic events, including sagittal sinus thrombosis, can have underlying genetic causes.
- Protein S deficiency is an inherited disorder associated with an increased risk of thrombosis.
- Family history is crucial in identifying potential genetic predispositions to thrombotic disorders.
Abstract:
A 30-year-old man presented with sagittal sinus thrombosis. He had a history of multiple thrombotic events since adolescence, and his father had had a similar history. Laboratory studies revealed the complete absence of free protein S in his plasma. Protein S deficiency, an autosomal dominant disorder, is an identifiable cause of cerebral thrombosis. The literature and our experience with this case suggest that long-term anticoagulant therapy may prevent thrombotic episodes in patients with this disorder.