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Updated: Jun 3, 2026

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction
Published on: March 29, 2024
Equine hyperlipidemias
1Marion duPont Scott Equine Medical Center, Virginia/Maryland Regional College of Veterinary Medicine, Virginia Polytechnic and State University, 17690 Old Waterford Road, Leesburg, VA 20176, USA. hmckenzi@vt.edu
Abstract:
Hyperlipidemia is the presence of elevated lipid concentrations in the blood and is associated with periods of negative energy balance and physiologic stress. In increased concentrations, circulating lipids typically occur in the triglyceride form, which may interfere with numerous normal physiologic functions, particularly by reducing insulin sensitivity. Although the hyperlipidemia risk is greatest in ponies, miniature horses, and donkeys, all equids are at risk if they are in a situation involving negative energy balance. The sedentary lifestyle of many modern horses and the frequent feeding of high-carbohydrate diets contribute substantially to the risk of excessive fat mobilization and the development of hyperlipidemias.
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