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Percutaneous endoscopically assisted transenteric full-thickness gastric biopsy: initial experience in humans
Christopher N Andrews1, Paul Mintchev, Emil Neshev
1Centre for Digestive Motility, Division of Gastroenterology, Department of Medicine, University of Calgary, Medical Clinic, Calgary, Alberta, Canada. candrews@ucalgary.ca
Gastrointestinal Endoscopy
|March 12, 2011
Summary
A novel percutaneous endoscopically assisted transenteric (PEATE) biopsy is a safe and effective method for diagnosing gastric neuromuscular diseases. This outpatient procedure successfully obtained tissue for histological analysis in 90% of patients, aiding in GINMD diagnosis.
Area of Science:
- Gastroenterology
- Histopathology
- Surgical Innovation
Background:
- Gastrointestinal neuromuscular diseases (GINMD) present with significant dysmotility and symptoms.
- Full-thickness gastric biopsies are crucial for histological diagnosis of GINMD.
- Current diagnostic methods may be invasive or require general anesthesia.
Purpose of the Study:
- To evaluate a new percutaneous endoscopically assisted transenteric (PEATE) biopsy technique.
- To assess the feasibility of obtaining full-thickness gastric tissue for diagnosing GINMD.
- To determine the safety and efficacy of the PEATE biopsy method.
Main Methods:
- Prospective proof-of-concept case series in a tertiary care setting.
- Ten patients with suspected gastric GINMD underwent PEATE biopsy during standard gastroscopy.
- Tissue analysis included histology and immunohistochemistry, with comparison of Interstitial cells of Cajal (ICC) counts to controls.
Main Results:
- Successful full-thickness gastric tissue acquisition in 90% of patients (9/10).
- The PEATE biopsy procedure was well-tolerated and complication-free.
- Histological analysis suggested GINMD in 44% of cases, including leiomyopathy and abnormal ICC networks.
Conclusions:
- PEATE biopsy provides a simple and safe endoscopic approach for gastric tissue sampling.
- This method facilitates histopathological assessment of gastric GINMD.
- It avoids the need for laparoscopy and general anesthesia, offering a less invasive diagnostic option.
