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Updated: Jun 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antibiotic use: knowledge and perceptions in two university hospitals.

Jean-Christophe Lucet¹, Marie-Hélène Nicolas-Chanoine, Carine Roy

¹Infection Control Unit, Bichat-Claude Bernard Hospital, Assistance publique-hôpitaux de Paris, and Denis Diderot University, Paris, France. jean-christophe.lucet@bch.aphp.fr

The Journal of Antimicrobial Chemotherapy

|March 12, 2011

Summary

Physician knowledge of antibiotic prescription varies. Surgeons scored lower, indicating a need for targeted education. Cognitive factors influence antibiotic prescribing, informing future interventions.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Medical Education
Infectious Disease Management
Healthcare Quality Improvement

Background:

Antibiotic stewardship is crucial for combating antimicrobial resistance.
Understanding physician knowledge and perceptions is key to improving antibiotic prescribing practices.

Purpose of the Study:

To assess physician knowledge and perceptions regarding antibiotic prescription in university hospitals.
To identify factors influencing appropriate antibiotic use.

Main Methods:

Physicians evaluated case vignettes on infection management.
A questionnaire collected data on beliefs and perceptions of antibiotic prescription.
Analysis identified factors associated with vignette scores.

Main Results:

Physician participation rate was 50.2% (206/412).
Anesthesiologists/intensivists had higher scores, while surgeons had lower scores.
Perception of risk from inappropriate antibiotic use and self-efficacy were associated with higher scores.

Conclusions:

Physician awareness of antibiotic use is high, as suggested by participation rates.
Targeted educational programs for surgeons are necessary.
Identified cognitive factors can inform the design of interventions to improve antibiotic prescribing.