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Exercise-induced cardiac preconditioning: how exercise protects your achy-breaky heart.
Chad R Frasier1, Russell L Moore, David A Brown
1Dept. of IPhysiology, Brody School of Medicine, East Carolina Univ., Greenville, NC 27834, USA.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 12, 2011
Summary
Regular exercise, even for a single day, can protect the heart from ischemia-reperfusion injury. This sustainable preconditioning effect involves cellular adaptations, highlighting exercise
Area of Science:
- Cardiovascular Physiology
- Exercise Science
- Cellular Biology
Background:
- Exercise is recognized for its cardioprotective effects against ischemia-reperfusion (I/R) injury in humans and animal models.
- Exercise preconditioning offers a sustainable stimulus for cardiac protection, lasting from days to months.
Purpose of the Study:
- To review current knowledge on exercise preconditioning of the heart against infarction.
- To explore the mechanisms underlying exercise-induced protection against I/R damage.
Main Methods:
- Review of existing literature on exercise and cardiac I/R injury.
- Analysis of studies investigating the cellular and molecular adaptations to exercise.
Main Results:
- Exercise, even short-term, confers significant protection against I/R injury.
- Protection is dependent on exercise model and intensity.
- Mechanisms involve enhanced oxidant buffering, ATP-sensitive potassium channels, and mitochondrial adaptations.
Conclusions:
- Exercise is a potent and sustainable preconditioning stimulus for the heart.
- Further research is needed to fully elucidate the mechanisms of exercise preconditioning against I/R damage.
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