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Glycosaminoglycans

Glycosaminoglycans

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...

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Updated: Jun 3, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hyaluronic acid hydrogels for biomedical applications.

Jason A Burdick¹, Glenn D Prestwich

¹Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA. burdick2@seas.upenn.edu

Advanced Materials (Deerfield Beach, Fla.)

|March 12, 2011

Summary

This summary is machine-generated.

Hyaluronic acid (HA) hydrogels are versatile biomaterials for tissue repair. Chemically modified HA can be engineered into various forms, offering solutions for cell therapy and regenerative medicine.

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Area of Science:

Biomaterials Science
Regenerative Medicine
Polymer Chemistry

Background:

Hyaluronic acid (HA) is a naturally occurring polysaccharide vital for cellular and tissue functions.
HA has a long history of clinical use and can be chemically modified into diverse physical forms.
These forms include hydrogels, fibers, meshes, and sponges for various applications.

Purpose of the Study:

To review recent advances in hyaluronic acid-based hydrogels for biomedical applications.
To discuss the development of HA hydrogels compatible with cell encapsulation and tissue injection.
To highlight HA hydrogels that meet clinical, regulatory, and financial requirements.

Main Methods:

Chemical crosslinking of hyaluronic acid using addition/condensation chemistry or radical polymerization.
Engineering HA into various physical forms such as hydrogels, fibers, and sponges.
Evaluating HA-derived materials for compatibility with cell therapy and regenerative medicine.

Main Results:

Chemically modified HA can be fabricated into multiple forms, including injectable hydrogels.
HA-based hydrogels are suitable for encapsulating cells and delivering therapeutic agents.
Many HA hydrogels satisfy clinical and regulatory criteria for regenerative medicine.

Conclusions:

Hyaluronic acid-based hydrogels represent promising biomaterials for tissue repair and regeneration.
The versatility of HA allows for tailored material properties for specific biomedical needs.
HA hydrogels offer a viable platform for advancing cell therapy and clinical applications.