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Related Concept Videos

Riboswitches01:56

Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

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Articles linked to this work by shared authors, journal, and citation graph.

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Molecular recognition elements: DNA/RNA-aptamers to proteins.

Biochemistry (Moscow) Supplement. Series B, Biomedical chemistry·2020
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DNA Aptamers to Thrombin Exosite I. Structure-Function Relationships and Antithrombotic Effects.

Biochemistry. Biokhimiia·2019
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[Study of the quantity of interleukin-6 by SDS-PAAG electrophoresis and immuno-enzyme analysis in mixed saliva after rinsing the oral cavity with oligonucleotide specific.]

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Complex formation with protamine prolongs the thrombin-inhibiting effect of DNA aptamer in vivo.

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[Interaction of DNA Aptamers with the ATP-Dependent Lon Protease from Escherichia coli].

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A family of DNA aptamers with varied duplex region length that forms complexes with thrombin and prothrombin.

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Related Experiment Video

Updated: Jun 3, 2026

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

[Molecular recognition elements--DNA/RNA-aptamers to proteins].

V A Spiridonova

    Biomeditsinskaia Khimiia
    |March 15, 2011
    PubMed
    Summary

    DNA/RNA aptamers are novel molecular tools that bind strongly to disease-related proteins. These aptamers show potential as direct inhibitors and effective new therapeutics for widespread human diseases.

    Area of Science:

    • Biochemistry and Molecular Biology
    • Drug Discovery and Development

    Context:

    • DNA/RNA aptamers represent a novel class of molecular recognition elements with significant therapeutic potential.
    • Pathogenesis of widespread human diseases often involves specific protein targets.

    Purpose:

    • To review current data on DNA/RNA aptamers, focusing on their application against proteins implicated in human disease pathogenesis.
    • To highlight the potential of aptamers as direct protein inhibitors and therapeutic agents.

    Summary:

    • Aptamers, which are nucleic acid-based molecules, exhibit strong and specific binding to target proteins.
    • This review covers aptamers targeting serine proteases, cytokines, growth factors, influenza viral proteins, and nucleic acid-binding proteins.
    • The specific binding capabilities of aptamers position them as effective inhibitors of pathogenic proteins.

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    Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

    Published on: March 21, 2018

    Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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    Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

    Published on: November 1, 2019

    Related Experiment Videos

    Last Updated: Jun 3, 2026

    Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
    11:34

    Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

    Published on: August 9, 2019

    Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor
    09:33

    Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

    Published on: March 21, 2018

    Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
    06:52

    Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

    Published on: November 1, 2019

    Impact:

    • Aptamers demonstrate potential as a new and effective class of therapeutic molecules.
    • Their ability to directly inhibit pathogenic proteins offers a novel approach to disease treatment.
    • This research underscores the growing importance of aptamers in modern medicine and biotechnology.