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Frequency of intracranial aneurysms in patients with spontaneous intracranial hypotension

Wouter I Schievink1, M Marcel Maya

  • 1Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, California 90048, USA. SchievinkW@cshs.org

Journal of Neurosurgery
|March 15, 2011
PubMed

Insights

Patients with spontaneous intracranial hypotension (SIH) have a higher incidence of intracranial aneurysms. This study found a significant association between SIH and these vascular abnormalities, suggesting a potential link.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neurosurgery

Background:

  • Spontaneous intracranial hypotension (SIH) frequently causes daily persistent headaches.
  • A connective tissue disorder affecting intracranial arteries is suspected in SIH patients.
  • The relationship between SIH and intracranial aneurysms requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of intracranial aneurysms in patients diagnosed with SIH.
  • To compare aneurysm incidence in SIH patients versus a control group.

Main Methods:

  • A retrospective case-control study was conducted.
  • Magnetic resonance angiography (MRA) of the brain was used.
  • 93 SIH patients and 291 controls were included.

Main Results:

  • Intracranial aneurysms were found in 8.6% of SIH patients, versus 1.0% in controls.
  • This difference was statistically significant (p = 0.0007).
  • Most aneurysms in SIH patients were incidental findings.

Conclusions:

  • The frequency of intracranial aneurysms is significantly higher in patients with SIH.
  • This finding supports the hypothesis of a connective tissue disorder affecting intracranial vasculature in SIH.
  • Further research is warranted to elucidate the underlying mechanisms.
Abstract

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