Related Experiment Video
Updated: Jun 3, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
Two novel HLA class II alleles, DRB1*11:96 and DQB1*02:01:03, identified in Koreans
1Hallym Institution for Genome Application, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Dongan-Gu, Anyang, Korea. hlakw@hanmail.net
Two human leukocyte antigen (HLA) alleles, DRB1*11:96 and DQB1*02:01:03, exhibit a single nucleotide difference in exon 2 compared to DRB1*11:01:01 and DQB1*02:01:01. This finding is crucial for understanding HLA polymorphism.
Area of Science:
- Immunogenetics
- Molecular Biology
- Human Leukocyte Antigen (HLA) research
Background:
- Human Leukocyte Antigen (HLA) genes are highly polymorphic.
- Specific HLA alleles play critical roles in immune responses and disease susceptibility.
- Accurate identification of HLA allele variations is essential for clinical and research applications.
Purpose of the Study:
- To identify and characterize nucleotide differences between specific HLA alleles.
- To precisely define the genetic variations in DRB1*11:96 and DQB1*02:01:03 compared to closely related alleles.
Main Methods:
- Nucleotide sequencing of relevant HLA gene regions (exon 2).
- Comparative sequence analysis of DRB1*11:96 and DQB1*02:01:03 against DRB1*11:01:01 and DQB1*02:01:01.
Main Results:
- DRB1*11:96 differs from DRB1*11:01:01 by a single nucleotide substitution in exon 2.
- DQB1*02:01:03 differs from DQB1*02:01:01 by a single nucleotide substitution in exon 2.
Conclusions:
- The identified single nucleotide polymorphisms (SNPs) represent distinct allelic variants within the HLA system.
- These variations may have implications for HLA typing accuracy and immunological function.
- Further studies are warranted to investigate the functional consequences of these specific nucleotide differences.
Related Concept Videos
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Multiple Allele Traits
Rh Blood Group
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Diversity of Antigen Receptors
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Single Nucleotide Polymorphisms-SNPs

