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Updated: Jun 3, 2026
07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Paracetamol (acetaminophen) use, fracture and bone mineral density
Lana J Williams1, Julie A Pasco, Margaret J Henry
1School of Medicine, Deakin University, Australia; Department of Psychiatry, University of Melbourne, Australia. lanaw@barwonhealth.org.au
Bone
|March 15, 2011
Summary
Regular paracetamol use may increase fracture risk in older women. This common pain reliever
Area of Science:
- Bone Metabolism and Osteoporosis Research
- Pharmacology and Drug Action
- Epidemiology and Public Health
Background:
- Paracetamol is a widely used analgesic and antipyretic.
- Its mechanism of action involves pathways that may influence bone metabolism.
- High community use necessitates investigation into potential skeletal effects.
Purpose of the Study:
- To investigate the association between paracetamol use, fracture risk, and bone mineral density (BMD).
- To examine these associations in women aged 50 years and older.
Main Methods:
- Case-control study within the Geelong Osteoporosis Study (GOS).
- Cases: 569 women with fractures; Controls: 775 women without fractures.
- BMD measured at multiple sites; medication and lifestyle factors self-reported.
Main Results:
- Paracetamol use was associated with increased odds of fracture (OR = 1.56).
- This association persisted after adjustment for BMD at spine, hip, and forearm.
- The association was attenuated but remained significant when total body BMD was included (adjusted OR = 1.46).
Conclusions:
- Paracetamol use appears to be a risk factor for fracture in older women.
- The underlying mechanism linking paracetamol to fracture risk requires further elucidation.
- Findings highlight potential implications for public health regarding widespread paracetamol use.
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